쓰스슥

AID is a 24 kDa enzyme that creates deliberate mutation in DNA.

AID removes the amino group from a cytidine base, turning it into a uridine (which is recognized as a thymidine). In other words, it changes a CG base pair into a UG base pair, which the cell's DNA repair machinery recognizes as a TG base pair, and finally ends up as a TA base pair.

In B cells in the lymph nodes, AID causes mutations that produce antibody diversity, but that same mutation process leads to B-cell lymphoma.

Immunoglobulin heavy locus, also known as IGH@, is a region on human chromosome 14 that contains a gene for the heavy chains of human antibodies (or immunoglobulins).

Myc (c-Myc) is a regulator gene that codes for transcription factor.
A mutated version of Myc is found in many cancers, which causes Myc to be constitutively expressed. This leads to the unregulated expression of many genes, some of shich are involved in cell proliferation and results in the formation of cancer.

In the human genome, Myc is loacted on chromosome 8 and is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases(HATs). This means that in addition to its role as a classical transcription factor, Myc also functions to regulate global chromatin structure by regulating histone acetylation both in gene-rich regions and at sites far from any known gene.

hypermethylation, hypomethylation이 뭔가?

In many disease processes, such as cancer, gene promoter CpG islandsacquire abnormal hypermethylation, which results in transcriptional silencingthat can be inherited by daughter cells following cell division. Alterations of DNA methylation have been recognized as an important component of cancer development. Hypomethylation, in general, arises earlier and is linked to chromosomal instability and loss of imprinting, whereas hypermethylation is associated with promoters and can arise secondary to gene (oncogene suppressor) silencing, but might be a target for epigenetic therapy.

Hypermethylation is one of the major epigenetic modifications that repress transcription via promoter region of tumour suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Global hypomethylation has also been implicated in the development and progression of cancer through different mechanisms.

• SearchData : table에서 검색할 데이터의 id와 컬럼 정보를 입력하면 해당 data를 찾아준다. (위치 : function_collection.R)